Covered Stent as an Optional Endovascular Approach to Treat Direct Carotid-Cavernous Fistula A Case Report
Abstract
Highlight:
- Direct CCF often mimics neuro-ophthalmic disorders, causing delayed diagnosis
- Covered stent is effective as a primary endovascular option for dCCF
- Risks of covered stent placement are stenosis, thrombosis and branch occlusion
ABSTRACT
Introduction: The use of covered stents has emerged as a treatment option for direct Carotid Cavernous Fistula (dCCF). However, it has not been routinely adopted in Indonesia. We report the first case in Indonesia of direct traumatic CCF successfully treated with a covered stent as the first-line endovascular therapy. Case: A 21-year-old woman with blurred vision, diplopia and swelling in the right eye, cranial nerves III and VI palsy with a history of traumatic fall two months prior. Digital Subtraction Angiography confirmed the presence of a right-sided direct carotid-cavernous fistula. Embolization was performed using a 3.5x16 mm Bentley covered stent at the fistula site. Direct embolization confirmed a type A right CCF resulted in complete obliteration and previous complaints were significantly reduced. Conclusion: Endovascular therapy with covered stents offers a promising treatment option for CCF, providing vessel patency and effective fistula occlusion. But the risk of complications should be considered.
Full text article
References
1. Cohen DA, Sanchez Moreno FR, Bhatti MT, Lanzino G, Chen JJ. Evaluating the Incidence and Neuro-Ophthalmic Manifestations of Carotid-Cavernous Fistulas. J Neuroophthalmol. 2024;44(2):232–5. DOI: 10.1097/WNO.00000000 00001973
2. Henderson AD, Miller NR. Carotid-cavernous fistula: current concepts in aetiology, investigation, and management. Eye. 2018;32(2):164–72. DOI: 10.1038/eye.2017.240
3. Barrow DL, Spector RH, Braun IF, Landman JA, Tindall SC, Tindall GT. Classification and treatment of spontaneous carotid-cavernous sinus fistulas. J Neurosurg. 1985;62(2):248–56. DOI: 10.3171/ jns.1985.62.2.0248
4. Jeong SH, Lee JH, Choi HJ, Kim BC, Yu SH, Lee JI. First line Treatment of Traumatic Carotid Cavernous Fistulas Using Covered Stents at Level 1 Regional Trauma Center. J Korean Neurosurg Soc. 2021;64(5):818–26. DOI: 10.3340/jkns.2020.0345
5. Yuan J, Yang R, Zhang J, Liu H, Ye Z, Chao Q. Covered Stent Treatment for Direct Carotid-Cavernous Fistulas: A Meta-Analysis of Efficacy and Safety Outcomes. World Neurosurg. 2024;187:e302–12. DOI: 10.1016/j.wneu.2024. 04.077
6. Pülhorn H, Chandran A, Nahser H, McMahon C. Case Report: Traumatic Carotid-Cavernous Fistula. J Trauma Nurs. 2016;23(1):42–4. DOI: 10.1016/j.radcr. 2022.02.065
7. Chaudhry I, Elkhamry S, Al-Rashed W, Bosley T. Carotid cavernous fistula: Ophthalmological implications. Middle East Afr J Ophthalmol. 2009;16(2):57. DOI: 10.4103/0974-9233.53862
8. Fattahi TT, Brandt MT, Jenkins WS, Steinberg B. Traumatic Carotid-Cavernous Fistula: Pathophysiology and Treatment: J Craniofac Surg. 2003;14(2):240–6. DOI: 10.1097/00001665-200303000-00020
9. Celik O, Buyuktas D, Islak C, Sarici Am, Gundogdu As. The association of carotid cavernous fistula with Graves′ ophthalmopathy. Indian J Ophthalmol. 2013;61(7):349. DOI: 10.4103/0301-4738.109533
10. Leishangthem L, Satti SR. Indirect carotid cavernous fistula mimicking ocular myasthenia. BMJ Case Rep. 2017;2017:bcr-2017-222048. DOI: 10.1136 /bcr-2017-222048
11. Kim D, Choi YJ, Song Y, Chung SR, Baek JH, Lee JH. Thin-Section MR Imaging for Carotid Cavernous Fistula. Am J Neuroradiol. 2020;ajnr;ajnr.A6757v1. DOI: 10.3174/ajnr.a6757
12. Santos DD, Monsignore LM, Nakiri GS, Cruz AAVE, Colli BO, Abud DG. Diagnóstico por imagem das fístulas arteriovenosas da região do seio cavernoso. Radiol Bras. 2014;47(4):251–5. DOI: 10.1590/0100-3984.2013.1799
13. Gemmete JJ, Ansari SA, Gandhi DM. Endovascular Techniques for Treatment of Carotid-Cavernous Fistula. J Neuroophthalmol. 2009;29(1):62–71. DOI: 10.1097/wno.0b013e3181989fc0
14. Hoffman H, Ashok Kumar A, Wood JS, Mikhailova T, Yoo JH, Wakeman MB, et al. Outcomes After Endovascular Treatment of Direct Carotid Cavernous Fistulas: Systematic Review and Meta-Analysis. World Neurosurg. 2023;170:e242–55. DOI: 10.1016/j.wneu.2022.10.123
15. Ng B, Fugger M, Onakpoya IJ, Macdonald A, Heneghan C. Covered stents versus balloon angioplasty for failure of arteriovenous access: a systematic review and meta-analysis. BMJ Open. 2021;11(6):e044356. DOI: 10.1136/ bmjopen-2020-044356
16. Wang W, Li MH, Li YD, Gu BX, Lu HT. Reconstruction of the Internal Carotid Artery After Treatment of Complex Traumatic Direct Carotid-Cavernous Fistulas With the Willis Covered Stent: A Retrospective Study With Long-Term Follow-up. Neurosurgery. 2016;79(6):794–805. DOI: 10.1227/neu.000000000 0001266
17. Wroe WW, Zeineddine HA, Dawes BH, Martinez‐Gutierrez JC, Shah M, Spiegel G, et al. Treatment of Traumatic Direct Carotid Cavernous Fistula With a PK Papyrus Covered Stent: A Report of 2 Cases. Stroke Vasc Interv Neurol. 2023;3(6):e001015. DOI: 10.1161/SVIN. 123.001015
18. Vranic JE, Regenhardt RW, Awad A, Doron O, Rabinov J. Endovascular and medical management strategies for carotid-cavernous fistulas: A safety and efficacy analysis. Interv Neuroradiol. 2024;159101992 41261761. DOI: 10.1177/ 15910199 241261761
19. Lai XB, Li MH, Tan HQ, Luo BY, Zhu YQ, Wang J, et al. Predictors of in-stent stenosis and occlusion after endovascular treatment of intracranial vascular disease with the Willis covered stent. J Clin Neurosci. 2013;20(1):122–7. DOI: 10.1016/j.jocn.2012. 01.051
20. Rehman, Z. Endoleaks: Current concepts and treatments - A narrative review. JPMA. The Journal of the Pakistan Medical Association, 2021. 71(9), 2224-2229. DOI: 10.47391/jpma.03-345
Authors
Copyright (c) 2025 Annisa Bunga Nafara, Ahmad Sulaiman Alwahdy, Elsa Primadona Sulfana Putri

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.